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Filtered Search Results
TARGETMOL CHEMICALS INC HS-173 10MG
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Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. HS-173 is an effective PI3K(alpha) inhibitor (IC50 0.8 nM). purity: 99%
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Apexbio Technology LLC Methscopolamine 155-41-9 200mg
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Methscopolamine is a small-molecule antagonist targeting muscarinic acetylcholine receptors It is designed to inhibit these receptors thereby reducing acetylcholine-mediated signaling and regulating gastrointestinal secretions and motility Methscopolamine exerts its biological activity primarily through antagonism of muscarinic cholinergic receptors Based on these pharmacological properties methscopolamine holds research potential in studying muscarinic receptor-mediated physiological processes particularly gastrointestinal functions and secretory mechanisms and in experimental models evaluating peripheral cholinergic receptor contributions to gastrointestinal disorders
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Medchemexpress LLC Gilteritinib | 1254053-43-4 | 200MG
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Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0 29 nM/0 73 nM respectively
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Apexbio Technology LLC CP-673451 343787-29-1 200mg
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CP-673451 (CAS 343787-29-1) is an ATP-competitive inhibitor with specificity for platelet-derived growth factor receptors (PDGFR- / ) It exhibits inhibitory potency with IC50 values of 10 nM for PDGFR- and 1 nM for PDGFR- while demonstrating significantly less inhibition toward kinases such as VEGFR-1 VEGFR-2 Lck TIE-2 and EGFR In cellular assays CP-673451 effectively inhibits PDGFR- phosphorylation in PAE- cells (IC50 6 4 nM) and reduces c-kit activity in H526 cells at micromolar range Its anticancer efficacy has been established by suppressing tumor growth and vascularization in xenograft models indicating its potential utility in cancer research and angiogenesis studies
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TARGETMOL CHEMICALS INC Crisaborole 200MG
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Also available in 1 mL, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Crisaborole (AN-2728) is a phosphodiesterase 4 inhibitor. Purity 99.91%
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Medchemexpress LLC MCC950 sodium | 256373-96-3 | 99.8% | 200 MG
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MCC950 sodium is a potent and selective NLRP3 inhibitor with IC50s of 7.5 nM in BMDMs and 8.1 nM in HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations and specifically inhibits NLRP3 but not AIM2, NLRC4, or NLRP1 activation.
- Potent and selective NLRP3 inhibitor
- Inhibits IL-1β but not TNF-α secretion
- Blocks canonical and non-canonical NLRP3 activation
- Specifically inhibits NLRP3 (not AIM2, NLRC4, or NLRP1)
- Reduces Interleukin-1β (IL-1β) production
- Attenuates severity of experimental autoimmune encephalomyelitis (EAE)
- Off-white to yellow solid appearance
- Purity of 99.8%
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Medchemexpress LLC Mezlocillin (sodium) | 42057-22-7 | 98.1% | 200 MG
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Mezlocillin (BAY-f 1353) sodium is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin sodium is active against both gram-negative and gram-positive bacteria. Mezlocillin sodium can be used in bacterial infection research.
- Semisynthetic and extended-spectrum antibiotic
- Active against both gram-negative and gram-positive bacteria
- Can be used in bacterial infection research
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Apexbio Technology LLC Sparteine 492-08-0 200mg
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Sparteine (CAS 492-08-0) is a naturally occurring alkaloid recognized for its activity as a ganglionic blocker It acts by competitively inhibiting neuronal nicotinic acetylcholine receptors thereby modulating synaptic transmission within the nervous system Owing to this specific mechanism sparteine is widely employed in neurobiological and pharmacological research to investigate neuronal signaling pathways and to elucidate mechanisms involved in central nervous system disorders Its use facilitates the exploration of neurotransmitter regulation and receptor function in experimental models
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Apexbio Technology LLC D-Pantothenate sodium 867-81-2 200mg
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D-Pantothenate sodium (CAS 867-81-2) is a water-soluble small molecule that serves as a biosynthetic precursor to coenzyme A (CoA) Through its conversion to CoA D-pantothenate sodium participates in vital cellular processes involving the metabolism of carbohydrates lipids proteins and nucleic acids It modulates metabolic pathways by influencing the activity of enzymes and associated signaling networks thereby contributing to cellular metabolic regulation This compound is frequently employed in studies investigating cellular metabolism disease models related to metabolic dysfunction and the biochemical mechanisms underlying enzyme-catalyzed reactions
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Apexbio Technology LLC D4476 301836-43-1 200mg
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D4476 (CAS 301836-43-1) is a selective cell-permeable inhibitor of casein kinase 1 (CK1) and ALK5 exhibiting IC50 values of 0 3 M for CK1 and 0 5 M for ALK5 (at 0 1 mM ATP in vitro) It likely acts via ATP-competitive inhibition of CK1 showing minimal to no significant inhibitory activity against SAPK2a/p38 PKB or SGK Treatment with D4476 inhibits CK1-mediated phosphorylation of FOXO1a (Ser322 and Ser325) and RhoB (Ser185) in H4IIE and HeLa cells respectively impacting downstream processes such as nuclear export dynamics and actin cytoskeleton regulation Additionally it induces partial p53-dependent growth arrest in HCT116 cells
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Medchemexpress LLC Resmetirom | 920509-32-6 | 99.9% | 200MG
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Resmetirom | 920509-32-6 | 99.9% | 200MG
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Medchemexpress LLC Urea, N-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1 | 219580-11-7 | MFCD08705327 | 99.9% | 523.7 g/mol | C28H41N7O3 | 200 MG
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PD173074 is a small-molecule research compound that potently inhibits fibroblast growth factor receptor 1 (FGFR1). It shows an FGFR1 IC50 of ~25 nM, inhibits VEGFR2 with an IC50 of 100-200 nM, and demonstrates approximately 1,000-fold selectivity over PDGFR and c-Src. It is supplied for laboratory research use as an analytical/research standard.
- Potent FGFR1 inhibitor (IC50 ≈ 25 nM).
- Also inhibits VEGFR2 (IC50 100-200 nM).
- Approximately 1,000-fold selectivity for FGFR1 over PDGFR and c-Src.
- High purity (≈99.9%).
- Molecular weight 523.7 g/mol.
- CAS number 219580-11-7.
- For research use only.
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Medchemexpress LLC Elesclomol | 488832-69-5 | >98.0% | 200MG
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Elesclomol | 488832-69-5 | >98.0% | 200MG
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Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 100g
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Methyl phenyl sulfone is a drug impurity
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![Medchemexpress LLC 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine | 1613710-01-2 | 99.7% | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233699.png-250.jpg)
Medchemexpress LLC 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine | 1613710-01-2 | 99.7% | 200 MG
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ARN-3236 (CAS 1613710-01-2) is an orally active, selective inhibitor of salt-inducible kinase 2 (SIK2) used for research applications. It potently inhibits SIK2 at sub-nanomolar concentrations, demonstrates anti-cancer activity in cell-based assays, and can sensitize cancer cells to paclitaxel-class agents.
- Oral active selective SIK2 inhibitor.
- IC50 for SIK2 <1 nM; SIK1 21.63 nM; SIK3 6.63 nM.
- Purity greater than 98.0% (HPLC).
- Molecular weight 336.41 g/mol; formula C19H16N2O2S.
- Available as solid and DMSO solution; multiple sizes including 200 mg.
- Intended for research use only; not for human use.
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